Score cirrhosis level composing result patient

Liver function tests you need to know

This is a blood test to detect abnormalities in the liver. Before taking the test, avoid heavy physical labor, do not eat high-fat foods, do not drink alcohol, do not smoke, and do not take medication (please notify your doctor if this is not possible). This article was reviewed and edited by Dr. Toxicologist. The fact that abnormal liver function will immediately lead to changes in blood composition, because the liver will continuously discharge a large amount of various substances into the blood. The liver rupture leads to the fact that certain substances begin to be released less, while others begin to release more. If you take blood from a person and analyze its components, you can draw conclusions about the state of the liver. The numbers describing blood components are called biochemical indicators. Among them, several are obvious, and their changes are characteristic or even specific to liver disease. These laboratory tests are called liver function tests or liver function tests. Functional-because the results of this test reflect the state of function, not the structure of the liver, even in the case of major structural abnormalities. Panels are usually called a set of heterogeneous tests, designed to obtain information about the state of any organ or system in the body. The panel has its own code because it can be distributed and executed as a whole. In addition, the stable grouping of laboratory tests includes a set of batteries (a set of similar tests when processing different biological materials in patients) and a ruler (a set of heterogeneous laboratory tests designed to achieve specific diagnostic goals). An example of the battery is the diagnosis group for diabetes, and an example of the line-the diagnosis group for rheumatism. Cirrhosis, tumor or inflammatory process in liver parenchyma; assess the stage of previously diagnosed disease and the effectiveness of treatment.
Unprotected sex, visits to the dentist, previous blood transfusions, intravenous drug use outside the medical facility, tattoos, abrasions and small cuts from the hairdresser or beauty salon).

When viral liver injury was suspected, authoritative research was conducted. Used to verify the diagnosis of viral hepatitis. At the same time, it is used to assess the degree of process activity in patients with chronic hepatitis. Please also read articles about which hepatitis test is more accurate, how to properly prepare for labor, and the shelf life of test results. Esophageal varices, which is a sign of liver cirrhosis. When looking for the cause, alcohol, drugs, viruses and autoimmune hepatitis, hemochromatosis, and Wilson's disease were excluded. In addition to changes in liver index levels, her sugar level continued to rise. Despite the advice of an endocrinologist, the patient could not control it. Because I didn’t understand the reasons for her liver changes, I sent her to consult with an experienced liver disease specialist. He found that the changes in the liver (fatty liver disease, converted to cirrhosis) were developed without the control of diabetes. . This happens, Zanesfield so sugar and cholesterol levels must be controlled.
Any medical institution with a clinical laboratory. The collection of biomaterials is done from the patient's vein (traditionally, it is done in an empty stomach, but this has no particular effect on the results).
If the patient ignores these requirements, the results obtained may be distorted. Explain that the data obtained should be expert's ability. Consider the age and sex of the patient, the individual characteristics of the accompanying disease and organism.
It is a free bile pigment just formed by hemoglobin. It enters liver cells and binds to glucuronic acid, thus becoming bound (direct) bilirubin. It is the gallbladder that stores the gallbladder. From there, bile is injected into the intestines along with direct bilirubin to help digest fat. He dyed the stool brown.

Liver examinations are often prescribed to patients suspected of having digestive and circulatory diseases. One of the indicators of this analysis is bilirubin (total score and score). Its number will change with the increase of damage to liver cells (working cells of the liver) or damage to red blood cells (erythrocytes), accompanied by biliary stagnation. In this case, hemoglobin is released, and under the action of enzymes, hemoglobin is broken down into two parts: hemoglobin and heme. The remaining part of heme is converted into biliverdin through a biochemical reaction, thereby producing the first part of bilirubin. This is a highly toxic substance, so the body will try to detoxify and clear it out faster-the liver can accomplish this task.

This means that it can be transported only when it binds to the transporter albumin. Indirect bilirubin and glucuronic acid special enzyme combination (conversion or combination) under the action of liver cells. As a result, the second part is formed: direct, bound or bound bilirubin.

In the large intestine, rectal bilirubin is exposed to the microbial flora and first becomes urobilinogen, and then 91% of the substance forms cholestin and cholerin, giving human feces a characteristic dark brown.
Due to different analytical methods, laboratories are also different. If you deviate from the norm, you should consult a doctor.

If the baby is alert and the bilirubin level in the blood gradually returns to normal, there is no need to treat neonatal jaundice. In healthy male and female adults, the blood pigment content usually does not increase by more than 21-22μ. The pregnancy period of women is an exception. The bilirubin value of pregnant women may fluctuate, depending on the initial health of the pregnant woman and gestational age. As the fetus grows, compression of internal organs (especially the liver and bile ducts) will occur, leading to stagnation. According to the analysis, the direct score may increase with the normal total bilirubin. As the level of bilirubin increases during pregnancy, especially as other liver function tests change, tests are needed. Appears as a slight increase in bilirubin or as yellowing of the skin and visible mucous membranes (jaundice). The main sign, in this case can be said that bilirubin is high. The second most important symptom is discoloration of stool and black urine.

This includes diseases in which the breakdown of red blood cells is increased. For example, hereditary or autoimmune hemolytic anemia, nocturnal hemoglobinuria, thalassemia. In this case, the blood content will increase at the normal level of direct fraction. The stool is normal in color, and the urine may be slightly darker. Hepatocyte pathology. Damage to liver tissue leads to the destruction of bilirubin metabolism, so both parts of the blood are increased, but increased. For example, this is caused by viral, toxic and alcoholic hepatitis. The stool is discolored, and the urine is obviously black. Pathology under the liver. The cause is obstruction of the liver duct (obstruction or compression). This leads to an increase in the concentration in the blood. For example, this may be related to gallstone disease, pancreatic cancer, and parasitic diseases. Urine will turn black and stool will become lighter. A special group consists of genetic diseases, in which the content of one or the other pigment increases. Unconjugated serum bilirubin is increased in Gilbert and Krigler-Nayid syndrome. Rotor, Darbin and Johnson syndrome are both elevated.

With liver cirrhosis, bilirubin can be maintained in the normal range for a long time, and has begun to increase with the development of complications. If the blood donation is not properly prepared, sometimes the test can show low bilirubin. The red blood cells of newborns have a shorter lifespan because they contain immature (fetal) hemoglobin, which is needed in the womb. After birth, fetal hemoglobin begins to rapidly decompose and is replaced by adults; due to the immaturity of the enzyme system, newborn liver slowly solves this indirect bilirubin detoxification problem.
During pregnancy, necessary examinations must be performed to determine potential conflicts and conflicts based on blood type, and treat them if necessary. In this case, the most important thing is to constantly observe and implement the doctor's advice in the prenatal clinic.

This indicator measures the liver's ability to synthesize protein. Lower albumin levels mean that the liver cannot properly process amino acids in food. Therefore, it can maintain the normal osmotic pressure in the blood. Transport and distribute various compounds (electrolytes, drugs, nutrients) to human tissues. The albumin standard for adults is 37 to 57. However, its concentration may decrease.
In the pathology of urinary organs, protein is lost through the renal tubules; due to the damage of liver cells, the liver synthesis function is impaired. After destroying liver cells, aminotransferases will be found outside the cell membrane, and their activity in the blood will increase. Signals in the blood indicate liver damage. information chart.
Compared with, this is a more liver-specific index, and it may increase with the increase of especially the destruction of myocardial fibers (myocardial infarction).
Not only can blood in the blood indicate a problem with the liver, but it can also indicate problems with other organs that may affect the liver. Read medical stories about rare causes of elevated liver enzymes.

It is necessary to start independent intake of essential phospholipids, herbal preparations based on milk thistle or milk thistle. They are useless in treating the causes of liver disease and have no effective effect.
In another article, learn more about these and other liver enzymes and what the test results can tell your doctor.

In the recovery phase, first normalize the value of albumin, and then normalize the gamma globulin. The conversion to the chronic form is characterized by a continuous increase in the globulin score. The thymol test is usually used to assess liver function after hepatitis.
In the biochemical analysis of gallbladder bile, the diagenetic (lithogenic) index-cholesterol, cholesterol coefficient, Rubens index, swelling index, Thomas-Hoffman index were determined.
Its maximum solubility limit can be dissolved in the test sample. The meaning of the lithology index must be remembered in order to understand the description and make a wise choice of many liver drugs.
In all forms of hepatitis, peripheral blood flow increases. The definition of its score is used alone to understand why people suffer from jaundice. An increase in indirect bilirubin indicates increased breakdown of red blood cells, and an increase in direct bilirubin indicates problems with the liver or biliary system. The accompanying jaundice will increase the content of unconjugated bilirubin, while the content of the direct part is normal; when the biliary tract is obstructed (mechanical or obstructive jaundice), the level of conjugated bilirubin will increase; with the destruction of liver parenchyma ( The development of viruses, poisons, alcohol) and inflammation (hepatitis) will increase in both parts. For liver cirrhosis and liver fibrosis, the level of bilirubin can remain normal for a long time, and then slightly increase.

Elevated alkaline phosphatase in cholestasis (cholestasis) diseases: liver cirrhosis, hepatitis, oncology. However, it will increase with pathological changes in other organs (kidney tumors, bone diseases). The measurement of serum albumin helps to evaluate the synthetic function of the liver, which is disturbed in various pathological processes (inflammation, necrosis, cirrhosis, oncology). With fatty liver disease, the acute course of viral chronic hepatitis aggravates or worsens, the transition to liver cirrhosis, and the increase in peripheral blood. The more active the inflammation, the higher the level of transaminase. High values ​​can also indicate heart disease (heart attack).

In order to find out which organ is affected, the ratio of enzyme activity can be determined by dividing the value by (German coefficient). If the coefficient is less than 0.8, the liver is damaged; if the coefficient is greater than 1.0, the heart is damaged. Go to the doctor and find out the cause when the liver parameters are elevated. Because treatment depends on the cause. And, the earlier the cause is discovered and treatment is started, the higher the possibility of the course of the disease developing. You can ask the hepatologist questions in the comments. Ask, don't hesitate! Article published: Last update of the article: Can't find what you want?

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